1800+ AMD, 512 RAM, Geforce Ti4600 here and I could run many options on and run quite smoothly. Cities are difficult to get through as my system bogs down horribly in them, but dungeons and open areas like Antonica it's sweet and beautiful.
I must say that the lack of beastlords is a fair bit glaring.. just can't replace them
Presently I'm running a lvl 20 Kerran Dirge
http://www.users.qwest.net/~pojodan/EQ2Mish.JPG <older pic>
They just recently added in Kerran 'grunts', which are, IMHO, perfect as they sound more big-cat-ish.
Another BIG plus is animations.. oh gawd how I loathed EQ1 animations for Vah Shir.. jerky, awkward, and just plain bleck.. now my Kerran's tail moves indipendantly of what she's doing so wether standing or running it sways side to side slowly and naturally. Combat animations are beautiful and natural (Crouched slightly with a wide stance, no widely flailing arms) plus you auto-face your opponent once combat is engauged so no more 'not facing target' messages.
On the topic of locked combat: It's really not such a bad thing. In many ways is actually make sence. The way I see it our avatars show respect for those around them by not interfiering with their battles unless they ask for help. It would be nice if SOME experience was still to be had for killing them and maybe junk loot (Say the Sword of Uberness becomes a Damaged Sword of Uberness that's too damaged to be useable), but over all it's not so bad. This also allows soloers to have a chance in dungeons. I was lurking around Vermin Snye (Think Qeynos Catacombs) and was able to still fight cubes (Yup, those are still around) despite there being a full group or two standing right beside me.
#1 best part: Voice overs. Oh lordy how this changes things! And what's best is that the voice overs are WELL DONE. You actually get a feel for the sence of urgency for Scribe Jeblot's need for Mrs. Grubbyhand's muffin recipee over in Baubleshire when he audably speaks to you. As you wander through the city you overhear conversations and people greet you as you pass by (Admitedly, some of them are rather cheesy). NPCs also react to you, so if you've done Sgt. Grimlot's quest to kill rats he'll bow to you when you pass by or do some other emote to indicate that he likes you while when you first came to town and lacked citizenship he'd either ignore you or give you a scornful look. There's also ambiant animals
http://www.users.qwest.net/~pojodan/Ducks.JPG That quack, meow, bark, etc as they walk around aimlessly.
Quests: Prepare to be overloaded with quests! My 20 bard has about 120 or more quests completed, most of them FedEx type, and still using several items obtained with quests. ALl quests are doable by everyone since the reward is always exp, coin, and occationally an item. All jewelry items are usable by everyone, and when the reward is a weapon or armor you get to chose between several options so that no one's left out. If a quest is class specific (Which is either Hallmark quests for obtaining specific classes) or armor quests (Which there are 2 or 3 of for light/medium/heavy) then the others can't even start the dialogue to begin the quest. Another neat feature is location finding exp, as in when you first encounter the entrance to Blackburrow there will be a fanfaire of music, text on the screen, and you'll be rewarded a sizable chunk of exp. One can practically gain a full level or more just by walking around at the early stages.
Combat: Combat is fun. Heroic Opportunities, while hard to pull off in a group, can make things rather interesting if you can plan them out. I can barely kill a green if I just hack away at a MoB with my bard, but with the use of Heroic opportunities I can take out even cons without much trouble. Assisting is also a breeze as you need meerly target the MT and you'll automatically attack what he's attacking, even if he switches.. The only drawback being you get his health bar in the target window and you have to manually deactivate combat mode when the encounter is finished... but since heath bars above NPCs are easy to see (lots of options for coloring, when health bars show up, if names are showed or not and what color/size they'll be... I personally have PC names off with Health bars for NPCs always showing with names appearing with mouseover)
Overall feel: There's some minor gripes, like the number of zones one has to go through to get to some places and the lack of shrink spells (dungeons get really crowded), but over all it looks beautiful and plays quite well with lots of surprises along the way.
There's SOOO much more I'm missing, but I'm sure you can find details just about anywhere.
Oh, and, hoorah for graphical bugs:
http://www.users.qwest.net/~pojodan/Topless.JPG